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Se deficiency, especially in the second trimester, has been found to be associated with OS and an increase in inflammatory mediators [162], affecting the risk of developing pregnancy disorders by reducing placental GPX activity and impeding the function of other Se-dependent antioxidants, including thioredoxin reductases (TXNRD), thereby leading to placental OS [163]

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Zero pain improvement after 4 weeks for musculoskeletal conditions